Disease Manifestations APS Type 1 is a rare genetic disorder caused by mutations of the AIRE gene. Mutations in AIRE lead to multi-organ system autoimmunity typified by three classic manifestations: Autoimmune Hypoparathyroidism: a malfunction of the parathyroid glands.  These glands secrete a hormone that regulates the body’s use of calcium and phosphorus.  Hypoparathyroidism can cause … Continue reading What is APS Type 1?